Guideline 4000 LP+™
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Catalog Number: MT-LPP
"FHC's Guideline LP+ system provides robust clinical recordings with all the flexibility of a research device."
-Jens Volkmann, MD, PhD, Chairman and Professor of Neurology, University Clinic of Würzburg, Germany
The microTargeting™ Guideline 4000 LP+™ neuromodulation targeting system features the power of the Guideline 4000™ in a light, portable package. Optimized for clinical use (user-specifiable channel count, streamlined setup, rugged design), the LP+ continues to support high-powered research (fully adjustable digital filters, wideband recording capabilities, straightforward data export and analysis). Featuring the Guideline 4000™ software version 2.0 release, the LP+ offers the most powerful targeting system on the market in a streamlined, affordable package.
- Up to five recording channels and three more auxiliary inputs permit recording multiple microelectrode and auxiliary biological signals simultaneously - for example, EMG, ECoG, EEG, EKG, and accelerometer.
- Advanced stimulation features make it easy to stimulate and record simultaneously and to use custom-designed stimulation protocols for neuroscience research and treatment.
- Fully integrated micro- and macro-stimulation and impedance check modules make it easy to stimulate and check impedance without switching cables.
- Digital audio equalizer and high-quality Bose® speakers provide exceptionally crisp sound by enabling the user to set the right mix for a clean, familiar audio experience.
- Open system structure and optional breakout box enable straightforward online or offline data export to NeuroExplorerTM, MATLABTM, or secondary recording/analysis system.
- Wide-band, independently adjustable digital filters permit recording of low-frequency signals, such as local field potentials, simultaneously with spiking data.
- Integrated line noise adaptive filter to minimize line noise pick-up for noise-free recordings.
- Proven durability and reliability.
- Worldwide technical support, training, and service available 24/7 to guarantee performance, reliability, and assistance when needed.
The microTargeting™ Guideline 4000 LP+™ offers neurosurgical teams the power of the Guideline neuromodulation targeting family in a compact, streamlined package. The LP+ places a priority on meeting the clinical requirements of a targeting system, offering fully integrated stimulation and impedance check capabilities on all channels, in addition to one-click recall of user preferences and side-by-side review of all recorded snapshots. The entire LP+ system fits into a single padded, lockable shipping case, making transport simple and convenient. Alternatively, the LP+ system can be permanently installed on an ergonomic cart with a locking cabinet and adjustable tabletop height. Modular by design, the LP+ can be configured to meet the specific needs of the customer, including user-specifiable channel count and optional drive accessories. Still, with independently-adjustable filter settings, ultra-wideband recording capabilities, and dedicated earth-referenced analog outputs for all channels, the LP+ can support the highest-powered research endeavors. Further, by providing seamless data export to MATLAB and NeuroExplorer, the LP+ enables users to create and run customized data analysis scripts, online or offline. Featuring simplified software and streamlined hardware, the LP+ is the latest generation of Guideline power, with an even stronger emphasis on reliability and usability.
- Powerful, easy-to-use software keeps the focus on the patient
- Multiple data record, display, and analysis modes facilitate selection of the optimal electrode track
- Straightforward data capture and archiving makes storage and analysis fast and simple
"I have worked with all of the commercially available microelectrode recording (MER) systems, and I think that the Guideline System is the best. The 2.0 software user interface is intuitive, the recording quality is excellent, and the micro- and macro- stimulation capabilities are unparalleled….”
- Michael S. Remple, PhD, Sr. Clinical Neurophysiologist, Asst Director of DBS program, Sentient, Inc.
Version 2.0 includes several new features - including advanced stimulation capabilities and a built-in digital audio equalizer - that deliver an improved user experience and serious research power.
Complex stimulation pulse pattern generation for maximum stimulation control and flexibility
- Create arbitrarily complicated stimulation pulse trains with included Pulse Editor software to test new stimulation protocols
- Load pulse trains from .WAV files for easy sharing and retrieval
- Load multiple pulse train files into software for convenient recall and use
- Change output amplitude on-the-fly to rapidly find optimal stimulation levels
Simultaneous stimulation and recording capabilities to facilitate research
- Stimulate on any channel and record simultaneously on other channels to
investigate stimulation effects at the cell and network level - View recordings on all channels live during stimulation to see effects online
- Use adaptive artifact remover to filter out stimulation artifacts and focus on the
cellular response
Integrated digital audio equalizer to fine-tune audio output
- Adjust bass and treble sound settings to easily adjust sound output to your liking
- Use advanced digital audio equalizer settings to completely control audio quality
User interface enhancements for easier and faster use
- Enter recording depth manually with new user control to easily save depth information with recordings
- Stimulate at lower frequencies and longer durations for simple and easy physiological testing and control
- Utilize stimulation slider controls to quickly and smoothly adjust stimulation settings
- Preselect number of stimulation train cycles or stimulation for precise control
Applicable Standards
General Standard: EN60601-1 General Electrical Safety
Collateral Standards: 60601-1-1, 60601-1-2, 60601-1-4, 60601-1-4, 60601-1-6
Particular Standard: EN60601-2-26
The Guideline 4000 LP+TM is a Class 2 medical device with a Type BF applied part.
Microelectrode Recording Channels
Specifications
Analog signal conditioning
Cable: 66-EL-LP or equivalent only.
Inputs: Differential (default) or single ended, AC Coupled.
Input 1013Ω ║ 0.2pF AC, 40-300 MΩ DC Differential
Impedance: 1013Ω ║ 7.0pF AC, 40-300 MΩ DC Common Mode
Gain:
Preamp: 50-520X
DSP: 0.25X to 665X user adjustable
Total: 54-7200X
Sampling Frequency: max 48 kHz (default), user adjustable
MER Preamp Configuration:
Upper frequency cutoff: 20kHz, 40dB/decade roll-off
Lower frequency cutoff 125Hz, 20dB/decade roll-off
LFP/EEG Preamp configuration:
Upper frequency cutoff: 20kHz, 40dB/decade roll-off
Lower frequency cutoff: 0.3Hz, 20dB/decade roll-off
System Noise (includes thermal noise)
MER: 300Hz-10kHz: <5uV/<10uV, 1Ohm/1MOhm input resistance
LFP/EEG: 1-35Hz: <0.5uV/<1uV, 1Ohm/1MOhm input resistance
Auxiliary Input/Output
Analog Inputs:
Quantity: two
Input Characteristics:
Coupling: DC coupled (default), AC configurable
Range: default -8.0V to +8.0V, factory configurable
Sampling Frequency: 0 to 5.0kHz
Earth referenced, non-isolated
Analog Outputs:
Quantity: Five
Range: AC Coupled, bipolar, -1.5 V to +1.5 V
Earth referenced, non-isolated
Propagation delay: 580 µsec, digital filters off
Digital Inputs:
Quantity: one
Input Characteristics: TTL compatible, 1KOhm pull-down internal
VIH: 2V min
VIL: 0.8V max
VI: 0 to 5V (20mA max input current)
Earth referenced, non-isolated
Stimulation
Implementation: isolated, constant current stimulator
Macrostimulation
Cathode: macro-contact of selected cathode electrode
Anode: patient common (default) or macro-contact of anode electrode according to user selection in software
Microstimulation and Impedance Check
Cathode: microelectrode contact of selected cathode electrode
Anode: patient common
Stimulus Current Amplitude:
Compliance Voltage: ±50V
Macrostimulation
Range: 0 to 10.0 mA P-P
Display Resolution: 10 µA
Accuracy: ±5%
Adjustments: continuous adjustment using remote control amplitude knob. Resolution of 0.1mA every 7.2° degrees.
Microstimulation
Range: 0 to 100µAP-P
Display Resolution: 1 µA
Accuracy: ±5%
Adjustments: continuous adjustment using remote control amplitude knob. Resolution of 1µA every 7.2° degrees.
Stimulus Waveform
Pulse Train Polarity: user selectable from following options
Biphasic negative going leading pulse (default)
Biphasic positive going leading pulse
Uniphasic positive pulse (macrostim only)
Uniphasic negative pulse (macrostim only)
Pulse Train Frequency: 1Hz-300Hz. Pulse Duration: 20.83 µs – 2999.95 µs. For biphasic pulses, the duration includes both phases of the pulse.
Custom stimulation pulse trains may be designed using Pulse Editor or MATLAB.
Stimulus Duration:
Manual: stimulus while user holds down the stimulate button on the remote control
Fixed Duration: 1-60 sec, user can cancel by pressing stimulate button a second time.
Train Cycles: User may specify number of stimulation train cycles per button press.
Impedance Check
Implementation: impedance measured from microelectrode to patient common, single channel at a time, multiple channels can be measured sequentially. Impedance result is displayed on notebook display and result is stored as an event.
Measurement Stimulus
Waveform: sine wave
Frequency Range: 100Hz ±5% to 5kHz ±5%. 1kHz default.
Amplitude: 10.0µA RMS
Duration: 1.0 to 10.0 sec. adjustable
Physical Specifications
Dimensions:
Height: 5.5” (bottom panel to top panel)
Width: 17” (left panel to right panel)
Depth: 15.25” (front panel to back panel)
Weight: 16.85 lbs (enclosure only)
Power Requirements
100-240 VAC, 50/60 Hz, 2A
MT-LPP
MT-LPP / Guideline 4000 LP+™, includes:
- One microelectrode channel, expandable up to five channels
- Ultra-wideband preamps (0.1 Hz – 20 kHz), software configurable to 240 Hz – 20 kHz
- Stimulation remote control
- High-powered laptop
- Optical mouse
- External, self-powered desktop speakers
- Technical support available 24 hours a day, 7 days a week
- On-site installation
- On-site training prior to first case
- On-site support for up to three cases
MT-LPP-MEPK / LP+ mobile electrophysiology kit: Includes a one-channel LP+ system, hard case, and microTargeting™ Controller, motor, and remote. Includes on-site training and installation.
MT-LPP-PHIK / LP+ permanent hospital installation kit: Includes a one-channel LP+ system, cart, and microTargeting™ Controller, motor, and remote. Includes on-site training and installation.
MT-CASE OEC / Onsite case support (includes travel): Includes technician, MER equipment, and consumables (single track configuration; array configuration also available, call for details).
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