Guideline 4000 LP+™

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Guideline 4000 LP+™

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Stay on the cutting edge of cranial targeting with the feature-rich Guideline 4000 LP+. The easy to use, familiar interface simplifies target localization without limiting data analysis and export options-- the LP+ manages the data while you focus on the patient.

Scaled to your Needs – The LP+ can be built with 1-5 channels for recording, stimulation, event tagging, LFP and spike analysis, and signal replay; up to 10 channels available for research users. Choose a portable case or cart with your complete system.

Quick Procedural Set-Up – Customizable preferences streamline set-up in the operating room. FHC will work with your team to pre-configure profiles for frameless, single and array configurations, as well as individual screen and report settings.

Crisp Audio – The LP+ delivers clear signals needed to navigate to target. New audio equalizer allows fine-tuning of the acoustical mix.

Stimulation Control – New features allow simultaneous stimulation and recording, and ability to test custom-designed stimulation protocols. Performing high-level research has never been easier.

Data Analysis and Export options – The LP+ has ample options for exporting data to MATLAB. Clinical users can now connect to their Waypoint Navigator to export depth and spike rate data for track visualization and analysis.

Reliable – The LP+ is durable and robust. FHC’s technical team provides on-site training and installation to ensure optimal performance and is available 24/7 to answer questions and provide operational support.

User profiles facilitate rapid operating room setup

Save equipment, recording, stimulation, and display preferences
Save multiple profiles on the same Guideline 4000™ system
Transfer profiles between systems
Factory-specified profiles provide known, “good” configurations
Onsite technical support sets initial profiles during system installation

A “raster” tab for viewing snapshots of all recorded events simultaneously

Recorded snapshots are displayed according to depth
Snapshots can be classified, color-coded, and replayed from the raster tab
Analysis mode plots root-mean-square voltage versus depth for raster snapshots, providing an additional track selection/target identification tool

Local field potential recording capabilities (with optional hardware upgrades)

Simultaneous low-frequency population and high-frequency spike data displays
Fully adjustable digital filters, sampling rate, adaptive line noise filter, and gain for each channel
Optional preamplifier hardware allows recording from 0.1 Hz-20kHz, 48 kHz sampling rate per channel
Optional “breakout box” to independently feed out channels to downstream recording/analysis systems
Export data directly to Matlab, Plexon or other data formats

Enhanced display configurability

Resize, undock, and move signal analysis windows and channel thumbnails
Drag windows and thumbnails to a second display
Drag auxiliary channels (for accelerometer, EKG, etc.) into analysis windows to change zoom and to resize
Switch between triggered spikes mode, chart recorder (continuous/oscilloscope) mode, and raster view mode
Simultaneously display spikes and chart recorder data for any channel

Improved stimulation and impedance check functions

Check impedance on multiple channels with one button press
Stimulate up to 60 seconds with one button press
Improved stimulation current readout

Contact FHC for free demo or on-site neuroCase trial

Applicable Standards:

General Standard: EN60601-1 General Electrical Safety
Collateral Standards: 60601-1-1, 60601-1-2, 60601-1-4, 60601-1-4, 60601-1-6
Particular Standard: EN60601-2-26
The Guideline 4000 LP+ is a Class 1 medical device with a Type BF applied part.

Physical Specifications

Dimensions:
Height: 5.5” (bottom panel to top panel)
Width: 17” (left panel to right panel)
Depth: 15.25” (front panel to back panel)
Weight: 16.85 lbs (enclosure only)

Power Requirements
100-240 VAC, 50/60 Hz, 2A

Microelectrode Recording Channels
Analog signal conditioning
Cable: 66-EL-LP or equivalent only.
Inputs: Differential or single ended Software configurable
AC/DC coupled, factory configurable
Input 1013Ω ║ 0.2pF AC, 200MΩ DC Differential
Impedance: 1013Ω ║ 7.0pF AC, 200MΩ DC Common Mode
Gain:
Preamp: 54 X
APM: 0.25X to 665X user adjustable
MER Preamp Configuration:
Upper frequency cutoff: 20kHz, 40dB/decade roll-off
Lower frequency cutoff 125Hz, 20dB/decade roll-off
Ultra-wide Preamp configuration:
Upper frequency cutoff: 20kHz, 40dB/decade roll-off
Lower frequency cutoff 0.2Hz, 20dB/decade roll-off

Auxiliary Input/Output
Auxiliary Input/Output Isolation from the patient circuit: (note: auxiliary IO jacks are earth referenced and not isolated from one another)
Dielectric Strength: >=4000VAC
Creepage Distance: >=4mm
Clearance Distance: >=2.5mm
Analog Inputs:
Quantity: two
Input Characteristics:
Coupling: factory configurable AC or DC coupled
Range: factory configurable from among following: (0-16V), (-8.0V to +8.0V), (0 to 4.0V), (-2.0V to +2.0V), (0 to 1.6V), (-800mV to +800mV), (0 to 400mV), (-200mV to +200mV), (0 to 160mV) and (-80mV to +80mV)
Bandwidth: 0 to 5.0kHz
Earth referenced, non-isolated
Analog Outputs:
Quantity: Five
Range: factory configurable: unipolar (0 to 3.0V) or bipolar (-1.5V to 1.5V) if bipolar, the output may also be AC or DC coupled
Earth referenced, non-isolated
Propagation delay: 580 µsec, filters off
Digital Inputs:
Quantity: one
Input Characteristics: TTL compatible, 1KOhm pull-down internal
VIH: 2V min
VIL: 0.8V max
VI: 0 to 5V (20mA max input current)
Earth referenced, non-isolated

Stimulation
Implementation: isolated, constant current stimulator with different ranges for microstimulation, macrostimulation and impedance checking. Stimulus waveforms are automatically routed to the appropriate contact as follows:
Macrostimulation
Cathode: macro-contact of selected cathode electrode
Anode: macro-contact of anode electrode or patient common according to anode selection
Microstimulation and Impedance Check
Cathode: microelectrode contact of selected cathode electrode
Anode: patient common
Stimulus Current Amplitude:
Compliance Voltage: ±60V
Macrostimulation
Range: 0 to 10.0 mAp-p
Display Resolution: 10 µA
Accuracy: ±5%
Adjustments: continuous adjustment using remote control amplitude knob. Resolution of 0.1mA every 7.2° degrees.
Microstimulation
Range: 0 to 100µAp-p
Display Resolution: 1 µA
Accuracy: ±5%
Adjustments: continuous adjustment using remote control amplitude knob. Resolution of 1µA every 7.2° degrees.
Stimulus Waveform (built-in square-wave):
Pulse Train Polarity: user selectable from following options
Bipolar positive going leading pulse (default)
Bipolar negative going leading pulse
Unipolar positive pulse
Unipolar negative pulse
Pulse Train Frequency: 1Hz-300Hz. Pulse Duration: 20.83 µs – 2999.95 µs note that for bipolar pulses, the duration includes both phases of the pulse.
Stimulus Duration:
Manual: stimulus while user holds down the stimulate button on the remote control
User customizable stimulation trains also supported.
Timed: user selectable from among the following options: 0.5 sec, 1 sec, 2 sec, 3 sec, 5 sec, 10 sec, 20 sec, 30 sec, 60 sec

Impedance Check
Implementation: impedance measured from microelectrode to patient common, software or hardware triggered, single channel at a time, multiple channels can be measured sequentially. Impedance result is displayed on notebook display and result is stored as an event.
Measurement Stimulus:
Waveform: sine wave
Frequency Range: 100Hz ±5% to 5kHz ±5%. 1kHz default
Amplitude: 1.0µA¬¬RMS
Duration: 1.0 to 10.0 sec. adjustable
Measurement Result
Range: auto-ranging 10M, 1M, 100k
Accuracy: ±10% of full range
Resolution: 2 digits
Remote Monitoring: Yes
Data Server: All spike sweeps (discriminated or not) and all chart recorder data as well as time stamps from digital inputs

Notebook Computer
Model: Dell Precision M6400
Processor: Intel® Core™2 Duo P8600, 2.40 GHz, 1067 MHz
Memory: 4.0 GB DDR3-1055 SDRAM
Video Card: 512 MB NVIDIA Quadro FX 2700M
Hard Drive: 80 GB Hard Drive 9.5 MM, 7200 RPMFFS
Display: 17 inch WXGA+ LCD screen

Speakers:
Model: Bose Computer MusicMonitor
Power: 100-240 V, 50-60 Hz AC
Driver: magnetically shielded, full range driver

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Guideline 4000 LP+™

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