Guideline 4000™

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Guideline 4000™

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The Guideline 4000™ Neuromodulation Targeting System enables you to perform intraoperative electrophysiological microelectrode recording, stimulating, data collection, analysis and storage.

Basic features of the Guideline 4000™ Neuromodulation Targeting System include:
• Configurable number of microelectrode recording channels (2-10 channels supported)
• Continuous, scrolling chart-recorder type data display for all active channels
• Analysis windows for high-fidelity data display (1-5 windows supported)
• Thumbnail windows to view all channels simultaneously (up to 10 channels)
• Support for simultaneous bilateral procedures
• Support for most common stereotactic equipment including the Medtronic Nexframe® and the microTargeting™ Platform
• Continually adjustable band-pass filters and adaptive line noise filters minimize noise pick-up
• Isolated, constant current stimulator capable of microstimulation (0-100µA) and macrostimulation (0-10 mA) on all channels
• Microelectrode impedance checking on all channels
• Remote data monitoring capabilities over network/internet connection

The Guideline 4000™ is designed for functional neurosurgery centers investigating and treating single- and multi-target movement disorders. Its versatile capabilities provide support for the use of up to ten microelectrodes simultaneously. An additional four auxiliary analog input channels and two auxiliary digital input channels are also available. Each microelectrode channel features optimized analog signal conditioning circuitry and a dedicated high speed digital signal processor allowing sophisticated real time analysis of the microelectrode signal.

The Guideline 4000™ is a highly integrated system with built in audio monitoring, impedance checking, and both micro and macrostimulation capabilities available for all electrode channels at the push of a button - no need to swap cables and/or electrode connections between multiple pieces of equipment. Additionally, tight integration with FHC’s microTargeting™ Controller allows intuitive graphical monitoring and automated recording of electrode depth throughout the entire procedure.

The Guideline 4000™ notebook computer provides a streamlined user interface. During the recording phase of a procedure, all channels are continually scrolled on screen in a chart recorder fashion. Software controls allow for quick and intuitive adjustment of everything from signal gain and filter settings to “spike” discrimination parameters. “Events” are created at any point of interest during the procedure. An event is used to store microelectrode recordings, audio/text notes, stimulation parameters and results, etc. Whenever possible, the type of neuron associated with an event may be identified by the user.

The Guideline 4000™ also maintains a functional model of the brain depicting various neural structures in a three dimensional model. Superimposed on this model is a representation of all microelectrode passes with events shown as small spheres in the appropriate location. These event spheres are color coded according to the type of neuron (or event) they represent. In this manner a visual aggregation of all the recorded data is presented to the user to assist in the final interpretation of the microelectrode generated data and to aid in the planning of subsequent phases of the procedure.

Main Power Requirements: 100/120/220/240 VAC 50/60Hz 400VA

Physical Specifications
Top and bottom case dimensions: H-36.8cm, W-55.9cm, L55.9cm
Top case weight: 31kg / 68 lbs
Bottom case weight: 34kg / 75 lbs

Microelectrode Recording Channel
Analog signal conditioning
Gain: Preamp – 54 X, APM - 1X to 133X user adjustable
Upper frequency cutoff: 20kHz, 40dB/decade roll-off
Lower frequency cutoff: 240Hz, 20dB/decade roll-off
Digital signal processing
Sampling: 48kHz , 16 bit resolution
Digital Bandpass Filter: High Pass - 0 – 1000Hz, Low Pass - 100-20000Hz
Polarity: Inverting (default, for extracellular recordings) or non-inverting
Adaptive line noise filter: adaptation weight adjustable from 0 to 10% per cycle
Waveform Analysis:
Chart Recorder Mode: scrolling rate adjustable from 5.00 sec/window to 0.25 sec/window
Spikes Mode: duration adjustable from 290µsec/sweep to 2.585 msec/sweep in 12 steps
Spike discrimination method: Level, Window or Adaptive Templates
Firing Rate: displayed in Hz based on discriminated waveforms, one second refresh rate

Auxiliary Input/Output
Digital Inputs: Quantity - one default, upgradeable to two
Earth referenced, patient-isolated
Analog Inputs: Quantity - two by default, upgradeable to four
Input Characteristics:Coupling: factory configurable AC or DC coupled
Range: factory configurable from among following: (0-16V), (-8.0V to +8.0V),(-4.0V to +4.0V), (0 to 1.6V), (-800mV to +800mV), (0 to 800mV), (-400mV to (0 to 160mV), (-80mV to +80mV), (0 to 80mV), (-40mV to +40mV)
Bandwidth: 0 to 20kHzEarth referenced, patient-isolated
Analog Output: Any microelectrode recording channel may be output to the analog output. Two configurations are available: single or enhanced analog output. Source channel(s) is(are) user selectable.
Quantity: one
Range: factory configurable: unipolar (0 to 4.0V) or bipolar (-2.0V to 2.0V) if bipolar, output may also be AC or DC coupled
Earth referenced, patient-isolated

Audio Monitor
Frequency Response: 80Hz to 22kHz
Power: 11W per channel (nominal)
Hardware Controls: Bass (±15dB), Treble (±15dB) and Volume
Software Controls:
Independent channel volume / mute controls
Audio Modes: all channels independently selectable
Raw: continuous conditioned audio playback
Threshold: only portions of the waveform exceeding the trigger level are played
Triggered: only portions of the waveform which trigger a sweep are played
Accepted: only portions of the waveform which are discriminated are played
Pulse: square pulse is played for every discriminated spike.

Stimulation
Compliance Voltage: ±50V, compliance warning above ±48V
Macrostimulation
Range: 0 to 10.0 mA
Display Resolution: 100 µA
Accuracy: ±5%, see performance graphs
Cathode: macro-contact of selected cathode electrode
Anode: macro-contact of anode electrode or patient common according to anode selection
Microstimulation
Range: 0 to 100µA
Display Resolution: 1 µA
Accuracy: ±5%, see performance graphs
Cathode: microelectrode contact of selected cathode electrode
Anode: patient common
Stimulus Waveform:
Pulse Train Phase and Polarity: user selectable from following options
Monophasic or biphasic
Cathode leading or anode leading biphasic pulses
Pulse Train Frequency: 10Hz, 20Hz, 30Hz, 50Hz, 75Hz, 100Hz, 125Hz, 150Hz, 175Hz, 200Hz, 250Hz, 300Hz.
Pulse Duration: 50, 75, 100, 150, 200, 300, 500, 1000µs
Stimulus Train Duration:
Manual: stimulus while user holds down the stimulate button on the remote control
Timed: user selectable (in seconds): 0.5 sec, 1 sec, 2 sec, 3 sec, 5 sec, 10 sec, 20 sec, 30 sec, 60 sec

Impedance Check
Implementation: impedance measured from microelectrode to patient common.
Measurement Stimulus
Waveform: sine wave
Frequency Range: 100Hz ±5% to 5kHz ±5%. 1kHz default
Amplitude: 1.0µA
Duration: 1.0 to 10.0 sec. adjustable
Measurement Result
Range: auto-ranging 10M, 1M, 100k
Accuracy: ±10% of full range
Resolution: 2 digits
Notebook Computer (minimum specifications)
Model: Dell Inspiron 9400 or Precision M6300
Processor: 2.00GHz Core 2 Duo
Memory: 2GB
17 Inch UltrasharpTM Wide Screen UXGA Display
Operating System: Windows XP Professional (SP3)
Hard Disk Capacity: 40GB
Removable Media: 8x CD/DVD burner

Printer
Type: Portable, full photolithography inkjet 4800 x 1200 dpi max.
Model: Canon Pixma iP90 series
Power: 100-240VAC 50/60Hz. <1W Standby, Approx. 10W printing
Interface: USB

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Catalog Number: MT-GL4K

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